Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial
Primary result · TIR (3.9-10.0 mmol/l)Result — go to the resultEstimated mean difference −0.6 percentage points 95% CI −2.4 to 1.1Authors' conclusion
Glucose control using the CamAPS FX algorithm with SMA was non-inferior to its use with CC in youth and young adults with type 1 diabetes.
Study context
- Population
- Youth and young adults (aged 12–20 years) with T1D using MDI, sensor-augmented pump or HCL before enrolment; two University Hospitals in Switzerland43 completed · sensor-augmented pump 4 · or HCL 7
- Participants
- 46 participants
- Comparison
- Simplified meal announcement (SMA) vs carbohydrate counting (CC) with mylife CamAPS FX HCL
- Primary endpoint
- Proportion of time glucose in target range (3.9-10.0 mmol/l); non-inferiority margin 5 percentage points
- Follow-up
- 3 month periods
Methodological detailscrossover, non-inferiority, two-centre
- Crossover
- Non-inferiority
- Two-centre
Primary result
TIR (3.9-10.0 mmol/l)
Estimated mean difference
−0.6 percentage points
95% CI −2.4 to 1.1
By group
SMAvs CC
estimated mean difference −0.6 percentage points (95% CI −2.4 to 1.1)
As reported in the abstract
Secondary outcomes
Time <3.9 mmol/l
Time >10.0 mmol/l
Total daily insulin dose · higher with SMA
P = 0.037
Time <3.9 mmol/l
- Similar between periods
Time >10.0 mmol/l
- Similar between periods
Safety
- Participants with serious adverse events, none intervention-related
- 3
Original publication
Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial. Diabetologia. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →