What is the Relationship Between Time in Range, Time in Tight Range, and HbA1c in Youth and Young Adults With Type 1 Diabetes? Results From the German/Austrian/Luxembourgian/Swiss Diabetes Prospective Follow-Up Registry
Authors' conclusion
Based on large, real-world data from a multinational registry, TIR and TTR correlated strongly, and both showed a good prediction of HbA1c. TTR estimates predicted from TIR were significantly higher in people with high glucose variability (CV).
Study context
- Population
- Youth and young adults aged ≤25 years with T1D for >3 months, DPV registry 2019–2022, with HbA1c and corresponding continuous glucose monitoring (CGM) profiles (12 preceding weeks, ≥80% completeness); median age 14.0 years (IQR 10.4–16.9)
- Participants
- 1,901 participants
- Outcome
- Relationship between TIR (70-180 mg/dL), TTR (70-140 mg/dL) and HbA1c
Methodological detailsmultinational registry, real-world data, correlation and adjusted regression models
- Multinational registry
- Real-world data
- Correlation and adjusted regression models
Main finding
As reported in the abstract
Correlations between TIR, TTR and HbA1c
Time in range (TIR) vs time in tight range (TTR) correlation, r (95% CI 0.962, 0.968), P < .001
0.965
TIR vs HbA1c correlation, r (95% CI −0.782, −0.745), P < .001
−0.764
TTR vs HbA1c correlation, r (95% CI −0.795, −0.759), P < .001
−0.777
Observational data: associations, not effects.
Further findings
- TTR estimates predicted from TIR significantly higher in high CV group (CV ≥ 36%), P < .001
Original publication
What is the Relationship Between Time in Range, Time in Tight Range, and HbA1c in Youth and Young Adults With Type 1 Diabetes? Results From the German/Austrian/Luxembourgian/Swiss Diabetes Prospective Follow-Up Registry. J Diabetes Sci Technol. Published 16 November 2024. doi:10.
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