Diabetes technology

A Comparison of Continuous Glucose Monitoring-Measured Time-in-Range 70–180 mg/dL Versus Time-in-Tight-Range 70–140 mg/dL

Diabetes Technol TherPublished Pooled analysis of continuous glucose monitoring (CGM) data from clinical studies

Authors' conclusion

TIR and TITR are highly correlated, although the relationship is nonlinear. With knowledge of TIR, TITR can be estimated with reasonable precision.

Study context

Population
Participants with T1D (9 studies, 912 participants) and T2D (2 studies, 184 participants) with CGM dataT1D 912
Participants
912 vs 184
Comparison
TIR 70-180 mg/dL vs TITR 70-140 mg/dL
  • T1Dn = 912
  • T2Dn = 184
Outcome
Relationship between CGM-measured TIR 70-180 mg/dL and TITR 70-140 mg/dL
Methodological detailsblinded or unblinded Dexcom sensors, stratified by coefficient of variation (CV) and TBR
  • Blinded or unblinded Dexcom sensors
  • Stratified by CV and TBR

Pooled result

As reported in the abstract

TIR-TITR relationship

Correlation between TIR and TITR

0.94

Further pooled results

TITR higher for a given TIR in T2D than T1D; differences minimized after adjusting for CV or TBR (both higher with T1D)

Original publication

A Comparison of Continuous Glucose Monitoring-Measured Time-in-Range 70–180 mg/dL Versus Time-in-Tight-Range 70–140 mg/dL. Diabetes Technol Ther. Published 13 October 2023. doi:10.1089/dia.2023.0380

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