Time in tight range and time in range for predicting the achievement of typical glucose management indicator and HbA1c targets
Authors' conclusion
TITR might be a more useful indicator than TIR of the achievement of typical GMI and HbA1c targets among adults with diabetes on insulin therapy.
Study context
- Population
- Adults with diabetes on insulin therapy, Samsung Medical Center, June 2019–December 2023, wearing Dexcom G6 or FreeStyle Libre CGM ≥90 days (sensor wear time ≥70%)
- Participants
- 773 adults
- Exposure
- Time in tight range (TITR) vs time in range (TIR) for predicting glucose management indicator (GMI) and HbA1c targets
- Outcome
- Ability (AUC, ROC analysis) of TITR vs TIR to predict achievement of typical GMI and HbA1c targets
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prediction of GMI <53 mmol/mol (7.0%) and <48 mmol/mol (6.5%)
- TITR had significantly greater AUC than TIR for predicting GMI <53 mmol/mol (7.0%) and <48 mmol/mol (6.5%) with Dexcom G6 or FreeStyle Libre
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Prediction of HbA1c <53 mmol/mol (7.0%), FreeStyle Libre usersGreater AUC with TITR | (95% CI 0.006–0.03) |
| Prediction of HbA1c <48 mmol/mol (6.5%), FreeStyle Libre usersGreater AUC with TITR | (95% CI 0.001–0.03) |
Variation across CV groups, HbA1c 48-53 mmol/mol (6.5-7.0%)
- TIR showed broader variations than TITR across CV groups
- Modifying effect of CV on TITR–GMI/HbA1c association minimised around GMI and HbA1c of 53 mmol/mol (7.0%)
Original publication
Time in tight range and time in range for predicting the achievement of typical glucose management indicator and HbA1c targets. Diabetologia. Published 7 May 2025. doi:10.
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