Association of Time in Range and Time in Tight Range With Cardiovascular Risk Factor Exposure in Youth With Type 1 Diabetes: A Cross‐Sectional Analysis on LDL Cholesterol and Blood Pressure Data From the SWEET International Database
Authors' conclusion
Key CGM metrics, particularly TIR and TITR, are independently associated with LDL-C and BP in youth with T1D
Study context
- Population
- Youth aged 6–18 years with T1D duration ≥ 1 year, not on antihypertensive or lipid-lowering therapy, with continuous glucose monitoring (CGM) profiles (≥ 14 days), lipid and blood pressure (BP) data, January 2019–June 2023; median age 14.3 years, T1D duration 5.6 years, 52.2% male
- Participants
- 3,328 participants
- Outcome
- Association of CGM metrics with LDL-C and BP
Methodological detailsinternational registry (SWEET)
- International registry (SWEET)
Main finding
As reported in the abstract
- Time in range (TIR) and time in tight range (TITR) inversely associated with BP-SDS and low-density lipoprotein cholesterol (LDL-C); Time above range (TAR), mean glucose, coefficient of variation (CV) and glycemia risk index positively associated
- all p < 0.01
- Models 1-3: TIR, TITR, TAR and glycemia risk index independently associated with LDL-C and systolic BP-SDS
- p < 0.001
- Models 1-3: CV independently associated with systolic BP-SDS
- p < 0.001
Observational data: associations, not effects.
Original publication
Association of Time in Range and Time in Tight Range With Cardiovascular Risk Factor Exposure in Youth With Type 1 Diabetes: A Cross‐Sectional Analysis on LDL Cholesterol and Blood Pressure Data From the SWEET International Database. Diabetes Obes Metab. Published 15 June 2026. doi:10.
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