Glycemic Variability and Time in Range Are Associated with the Risk of Overweight and High LDL-Cholesterol in Children and Youths with Type 1 Diabetes
Authors' conclusion
CGM metrics of glycemic control and variability were significantly associated with the risk of overweight in females and high LDL-c in both sexes.
Study context
- Population
- Children and youths with T1D with BMI, blood pressure (BP), lipid profile and continuous glucose monitoring (CGM) data
- Participants
- 895 children
- Exposure
- CGM metrics vs cardiovascular risk factors
- Outcome
- Independent associations between cardiovascular risk factors (CVRFs) (BMI >85th percentile, LDL-C >100 mg/dL, BP >90th percentile) and CGM metrics
Methodological detailsbinary multivariable logistic regression, sex-stratified, adjusted for confounding factors
- Binary multivariable logistic regression
- Sex-stratified
- Adjusted for confounding factors
Main finding
As reported in the abstract
Associations of CGM metrics with CVRFs
Time in range (TIR) <70% associated with LDL-C >100 mg/dL, males (OR)
3.2
TIR <70% associated with LDL-C >100 mg/dL, females (OR)
2.1
CV >36% associated with overweight, females (OR)
2.1
Observational data: associations, not effects.
Further findings
Correlations of CGM metrics with BMI percentile and LDL-C
- In both sexes, hypoglycaemia metrics and %CV positively correlated with BMI percentile
- LDL-C positively correlated with mean glucose and hyperglycaemia metrics
- LDL-C negatively correlated with TIR
Original publication
Glycemic Variability and Time in Range Are Associated with the Risk of Overweight and High LDL-Cholesterol in Children and Youths with Type 1 Diabetes. Horm Res Paediatr. Published 15 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →