Longitudinal study of arterial stiffness in pediatric patients with Type 1 Diabetes Mellitus (T1DM). Correlations with glycemic metrics derived from Continuous Glucose Monitoring (CGM) devices
Authors' conclusion
New glycemic metrics seem to serve as more sensitive and early predictors of CVD in young patients with T1DM. Further studies are needed to replicate and confirm these preliminary results.
Study context
- Population
- Youths with T1D; mean age 10.72 ± 3.35 yearscompleted 3 visits
- Participants
- 87 participants
- Exposure
- Time in range (TIR) improvers vs TIR non-improvers; HbA1c improvers vs HbA1c non-improvers
- Outcome
- Arterial stiffness (PWV, AIx@75) as early cardiovascular disease (CVD) indicators and associations with CGM-derived metrics
Methodological details3 visits at six-to-twelve-month intervals
- 3 visits at six-to-twelve-month intervals
Main finding
As reported in the abstract
Δ PWV Z-score for age and Δ systolic BP index
- TIR improvers showed significant improvement in Δ Pulse Wave Velocity (PWV) Z-score for age and in Δ systolic BP index
- No significant difference between HbA1c improvers and non-improvers
Observational data: associations, not effects.
Original publication
Longitudinal study of arterial stiffness in pediatric patients with Type 1 Diabetes Mellitus (T1DM). Correlations with glycemic metrics derived from Continuous Glucose Monitoring (CGM) devices. Diabetes Res Clin Pract. Published 29 January 2026. doi:10.
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