Association between continuous glucose monitoring metrics and clinical outcomes in adults with type 1 diabetes in a real-world setting
Authors' conclusion
This study quantifies HbA1c improvements with increased TIR and hypoglycemia reductions with improved CV in clinical practice.
Study context
- Population
- Adults with T1D using continuous glucose monitoring (CGM) (January 2014-July 2020), real-world setting
- Participants
- 542 adults
- Exposure
- CGM metrics vs HbA1c and hypoglycaemia
- Outcome
- Association of TIR with HbA1c (per 10 % increase in TIR)
Methodological detailslongitudinal, real-world setting
- Longitudinal
- Real-world setting
Main finding
As reported in the abstract
HbA1c reduction per 10 % time in range (TIR) increase, same visit
0.34 %
4 mmol/mol
HbA1c reduction per 10 % TIR increase, subsequent visit
0.20 %
2 mmol/mol
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted IRR |
|---|---|
| Level 2 hypoglycaemia by CVCV < 30 % vs CV ≥ 40.1 % · significantly reduced | 0.14 |
| Level 2 hypoglycaemia by CVCV 30-33 % vs CV ≥ 40.1 % · significantly reduced | 0.28 |
| Level 2 hypoglycaemia by CVCV 33.1-36 % vs CV ≥ 40.1 % · significantly reduced | 0.32 |
| Level 2 hypoglycaemia by CVCV 36.1-40 % vs CV ≥ 40.1 % · significantly reduced | 0.50 |
Hypoglycaemic events across HbA1c and coefficient of variation (CV)
- Hypoglycemic events were reduced at lower CV across HbA1c levels and at higher HbA1c across CV levels
Original publication
Association between continuous glucose monitoring metrics and clinical outcomes in adults with type 1 diabetes in a real-world setting. Diabetes Res Clin Pract. Published 1 May 2024. doi:10.
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