Sustained Follow-up of Automated Insulin Delivery in a Real-World Setting: Results at 2 Years of the French Nationwide Observatory OB2F
Authors' conclusion
In a large nationwide real-world cohort, AID use was associated with noninferior TIR between 12 and 24 months, significant improvements in glycemic outcomes compared with baseline, low rates of treatment discontinuation, and favorable safety outcomes.
Study context
- Population
- Children and adults with T1D initiating automated insulin delivery (AID) therapy in routine clinical practice, France (OB2F)2,225 with data at M24
- Participants
- 2,741 children
- Exposure
- Time in range (TIR) at M24 vs M12 of AID use
- M24n = 2,225
- Outcome
- TIR (70-180 mg/dL); noninferiority of TIR at M24 vs M12
- Follow-up
- 24 months
Methodological detailsnationwide, real-world, noninferiority (M24 vs M12)
- Nationwide
- Real-world
- Noninferiority (M24 vs M12)
Main finding
As reported in the abstract
TIR · M24 vs M12
Observational data: associations, not effects.
Further findings
| Outcome | M24 | Increase (%) | P value |
|---|---|---|---|
| TIR change, M24 vs baseline | 12.0 | P < 0.0001 | |
| HbA1c, baseline to M24M24 vs M0 | 7.1% | P < 0.0001 |
- TIR change by baseline HbA1c (<8% vs ≥8%) · M24 — Significant interaction between time of AID use and baseline HbA1c category · TIR remained higher with baseline HbA1c <8%
- P < 0.001 · P < 0.0001
- HbA1c, baseline to M24: M0 7.6%
- TIR change by baseline HbA1c (<8% vs ≥8%): sensitivity analysis, linear mixed-effects model adjusted for age, sex and diabetes duration
AID discontinuation · M24
- AID discontinuation at M24
- 2.1%
Safety
≥1 severe hypoglycaemia episode over preceding 12 months · M24 vs baseline
- Proportions lower at M24 than at baseline
Original publication
Sustained Follow-up of Automated Insulin Delivery in a Real-World Setting: Results at 2 Years of the French Nationwide Observatory OB2F. Diabetes Technol Ther. Published 10 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →