Adaptive Biobehavioral Control: A Pilot Analysis of Human–Machine Coadaptation in Type 1 Diabetes
Authors' conclusion
The results demonstrate that it is safe to integrate an AID system into the WIT ecosystem.
Study context
- Population
- Adults with T1D (17 female/13 male; age 40 ± 14 years; HbA1c 6.6% ± 0.5%)30 completed
- Comparison
- Control-IQ automated insulin delivery (AID) with Physiological Adaptation Module (PAM) plus Behavioral Adaptation Module (BAM) vs Control-IQ AID with PAM only
- Primary endpoint
- Safety of Web Information Tool (WIT)
- Follow-up
- 8 weeks
Methodological detailspilot, two-arm parallel
- Pilot
- Two-arm parallel
Primary result
As reported in the abstract
Safety: severe hypoglycaemia, DKA, other serious adverse events
- No severe hypoglycemia, DKA, or other serious adverse events were reported
Further findings
| Outcome | Experimental | Control | Estimate | P value | |
|---|---|---|---|---|---|
| TIR (70-180 mg/dL) · last 2 weeks of treatment | 74.6% | 73.8% | adjusted mean difference 2.65 % (95% CI −1.12%,6.41%) | P = 0.161 | |
| Time in 70-140 mg/dL · last 2 weeks of treatment | 50.7% | 49.2% | difference 5.71 % (CI 0.44%,10.97%) | P = 0.035 | |
| TBR · last 2 weeks of treatmentWithout increased TBR | difference 0.54 % (CI −0.09%,1.17%) | P = 0.089 | |||
| −5051015Difference, % (linear scale) |
Safety
Severe hypoglycaemia, DKA, other serious adverse events
- No severe hypoglycemia, DKA, or other serious adverse events were reported
Original publication
Adaptive Biobehavioral Control: A Pilot Analysis of Human–Machine Coadaptation in Type 1 Diabetes. Diabetes Technol Ther. Published 30 April 2024. doi:10.
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