Extended Use of Automated Insulin Delivery in Young People with Type 1 Diabetes and Elevated HbA1c: 52-Week Outcomes of the CO-PILOT Trial
Authors' conclusion
In young people with T1D and markedly elevated glycemia, longer term AID use with MM780G provided substantial, sustained improvements in glycemia without compromising safety.
Study context
- Population
- Young people (7–25 years) with T1D and baseline HbA1c ≥ 69 mmol/mol (8.5%)
- Participants
- 74 people
- Comparison
- Automated insulin delivery (AID) vs standard care
- AID firstn = 34
Methodological detailsmulticenter, 52-week, 13-week randomized phase, 39-week continuation phase, Pooled data presented for 39 weeks; 52-week data for the "AID first" group only, due to differing AID exposure times
- Multicenter
- 52-week
- 13-week randomized phase
- 39-week continuation phase
- Pooled data presented for 39 weeks; 52-week data for the "AID first" group only, due to differing AID exposure times
Primary result
As reported in the abstract
HbA1c · 52 weeks
| Group | Value | HbA1c % |
|---|---|---|
| AID first | mean 67 (SD 18) mmol/mol | 8.3 ± 1.6% |
AID first
Valuemean 67 (SD 18) mmol/mol
HbA1c %8.3 ± 1.6%
- Baseline mean HbA1c, all participants (n = 74)
- 92 ± 20 mmol/mol (10.5 ± 1.9%)
- Mean HbA1c at 39 weeks, all participants
- 67 ± 12 mmol/mol [8.3 ± 1.1%]
- Mean change in HbA1c at 13 weeks post-AID
- −28 [95% CI: −33, −23] mmol/mol or −2.5 [95% CI: −3.0, −2.1] percentage points
Further findings
- Time in range (TIR) (3.9-10 mmol/L) · 52 weeks — AID first
- mean 63.1 (SD 13.7) %
- TIR (3.9-10 mmol/L) — Baseline mean TIR, all available participants (n = 68)
- 23.1 ± 13.4%
- TIR (3.9-10 mmol/L): AID first n = 32
Psychosocial measures · 52 weeks
- Improved treatment satisfaction and reduced fear of hypoglycemia
Safety
| Outcome | Mean difference (events per 100 participant-years) |
|---|---|
| DKA rate vs 52 weeks before the trial | −35.7 |
DKA rate vs 52 weeks before the trial
- DKA rate decreased substantially
Severe hypoglycaemia
- No severe hypoglycemia occurred
Original publication
Extended Use of Automated Insulin Delivery in Young People with Type 1 Diabetes and Elevated HbA1c: 52-Week Outcomes of the CO-PILOT Trial. Diabetes Technol Ther. Published 5 March 2026. doi:10.
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