Automated Insulin Delivery for Young People with Type 1 Diabetes and Elevated A1c
Primary result · HbA1cResult — go to the resultBaseline-adjusted between-group difference −2.5 percentage points 95% CI −3.1 to −1.8Authors' conclusion
In this trial of 80 children and youth with elevated glycated hemoglobin, automated insulin delivery significantly reduced glycated hemoglobin compared with usual diabetes care, without resulting in severe hypoglycemia or diabetic ketoacidosis events.
Study context
- Population
- Children and youth aged 7 to 25 years with T1D and elevated glycemia (HbA1c ≥8.5% with no upper limit)all completed
- Participants
- 80 children
- Comparison
- AID vs usual care
- AIDn = 37
- Controln = 43reference
- Primary endpoint
- Baseline-adjusted between-group difference in HbA1c
- Follow-up
- 13 weeks
Methodological detailsmulticenter, open-label
- Multicenter
- Open-label
Primary result
HbA1c
Baseline-adjusted between-group difference
−2.5 percentage points
95% CI −3.1 to −1.8
P < 0.001
By group
AIDvs Control
baseline-adjusted between-group difference −2.5 percentage points (95% CI −3.1 to −1.8); P < 0.001
As reported in the abstract
Further findings
HbA1c at baseline
Time in target glucose range 70 to 180 mg/dl
- AID spent on average more time in range than control
- 8.4 hours
Safety
- Severe hypoglycemia events, Control
- 1
- DKA events, Control
- 2
- Severe hypoglycemia or DKA events, AID
- 0
Original publication
Automated Insulin Delivery for Young People with Type 1 Diabetes and Elevated A1c. NEJM Evid. Published 24 September 2024. doi:10.
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