Quality-Score (Q-Score) Can Be More Sensitive than %Time in Range and Several Other CGM Metrics in Detecting Responses to Therapeutic Interventions
Authors' conclusion
We observed consistent differences in sensitivity for the detection of the effects of therapeutic interventions, with Q-Score being superior to eight alternatives.
Study context
- Population
- People with T1D or T2D and poor glycemic control (HbA1c 8.2 ± 1.3%) using Libre 2 CGM, ∼8 days of in-hospital care with therapy changes by diabetes specialists
- Participants
- 120 vs 92
- Exposure
- Sensitivity of Q-Score vs Time in Range (TIR) and seven other CGM metrics for detecting effects of therapeutic interventions
- T1Dn = 120
- T2Dn = 92
- Outcome
- Relative sensitivity of CGM metrics (Student's t-values of paired pre/post differences) for detecting intervention effects
- Follow-up
- 3 days before admission vs 2 days before discharge
Methodological detailspre- vs postintervention paired within-subject comparison, in-hospital care
- Pre- vs postintervention paired within-subject comparison
- In-hospital care
Main finding
As reported in the abstract
Sensitivity for detecting intervention effect (Student's t-values)
- Q-Score showed the largest Student's t-values for T1D, T2D and pooled subjects, indicating better sensitivity than TIR or seven other metrics
Observational data: associations, not effects.
Further findings
Sensitivity of MODD (Q-Score component), T1D
- MODD showed the second-best sensitivity for within-subject changes in T1D
Original publication
Quality-Score (Q-Score) Can Be More Sensitive than %Time in Range and Several Other CGM Metrics in Detecting Responses to Therapeutic Interventions. Diabetes Technol Ther. Published 25 March 2026. doi:10.
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