Chronic Kidney Disease and Risk of Diabetic Ketoacidosis in Type 1 Diabetes
Authors' conclusion
A reduced eGFR (between 30 and 90 mL/min/1.73 m2) alone was not associated with increased DKA risk. This finding supports further research into potential kidney-protection benefits of SGLTi for selected individuals with type 1 diabetes.
Study context
- Population
- Individuals with T1D in the DCCT/EDIC study
- Participants
- 1,441 individuals
- Exposure
- Estimated glomerular filtration rate (eGFR) 30–90 vs eGFR 90–120 mL/min/1.73 m²
- Outcome
- First DKA event
- Follow-up
- 35-year data
Methodological detailstime-varying eGFR, Poisson and extended Cox proportional hazards models, 35-year follow-up
- Time-varying eGFR
- Poisson and extended Cox proportional hazards models
- 35-year follow-up
Main finding
As reported in the abstract
DKA rate
eGFR 90–120
0.65 events per 100 person-years
Observational data: associations, not effects.
Further findings
- Participants with diabetic ketoacidosis (DKA)
- 297
- DKA events
- 488
Original publication
Chronic Kidney Disease and Risk of Diabetic Ketoacidosis in Type 1 Diabetes. Diabetes Care. Published 27 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →