Associations of Kidney Tubular Biomarkers With Incident Macroalbuminuria and Sustained Low Estimated Glomerular Filtration Rate (eGFR) in Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC)
Authors' conclusion
Serial KIM-1 and sTNFR1 are associated with incident macroalbuminuria and sustained low eGFR in T1D.
Study context
- Population
- T1D participants of the DCCT/EDIC study; baseline mean diabetes duration 5.9 years, HbA1c 8.9%, eGFR 125 mL/min/1.73 m², AER 16 mg/day
- Exposure
- Tubular biomarkers and incident diabetic kidney disease (DKD)
- Outcome
- Incident macroalbuminuria (AER ≥300 mg/day) and sustained low eGFR (persistent eGFR <60 mL/min/1.73 m²)
Methodological detailstime-updated exposures, seven time points spanning ∼30 years
- Time-updated exposures
- Seven time points spanning ∼30 years
Main finding
As reported in the abstract
- Incidence of macroalbuminuria, cases per 1,000 person-years
- 4.8
- Incidence of low eGFR, cases per 1,000 person-years
- 3.5
- KIM-1 and macroalbuminuria, HR per 20% higher biomarker
- 1.11 (1.06, 1.16) (95% CI)
- KIM-1 and low eGFR, HR per 20% higher biomarker
- 1.12 (1.04, 1.21) (95% CI)
- sTNFR1 and macroalbuminuria, HR per 20% higher biomarker
- 1.14 (1.03, 1.25) (95% CI)
Observational data: associations, not effects.
Further findings
Mean biomarker values and subsequent low eGFR
- Mean KIM-1 and EGF-to-MCP-1 ratio were associated with subsequent low eGFR
Biomarker slope (per 20% increase) and subsequent macroalbuminuria / low eGFR
- KIM-1 increase and macroalbuminuria, HR
- 1.81 (1.40, 2.34) (95% CI)
- sTNFR1 increase and macroalbuminuria, HR
- 1.95 (1.18, 3.21) (95% CI)
- KIM-1 increase and low eGFR, HR
- 2.26 (1.65, 3.09) (95% CI)
- sTNFR1 increase and low eGFR, HR
- 2.94 (1.39, 6.23) (95% CI)
Original publication
Associations of Kidney Tubular Biomarkers With Incident Macroalbuminuria and Sustained Low eGFR in DCCT/EDIC. Diabetes Care. Published 14 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →