The Difference Between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate and Risk of Diabetic Microvascular Complications Among Adults With Diabetes: A Population-Based Cohort Study
Authors' conclusion
Large eGFRdiff was independently associated with risk of DMCs and its subtypes. Our findings suggested monitoring eGFRdiff in the diabetes population has potential benefit for identification of high-risk patients.
Study context
- Population
- Adults with diabetes free of diabetic microvascular complications at baseline (2006 to 2010), UK Biobank
- Participants
- 25,825 adults
- Exposure
- Lower vs higher eGFRdiff
- Outcome
- Incident overall diabetic microvascular complications (DMCs) and subtypes: DR, DKD and diabetic neuropathy (DN)
- Follow-up
- Median 13.6 years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
- Overall diabetic microvascular complications (DMCs), HR (95% CI) per 10% decrease in eGFRrediff
- 1.16 (1.14, 1.18)
- Diabetic retinopathy (DR), HR (95% CI) per 10% decrease in eGFRrediff
- 1.08 (1.05, 1.11)
- Diabetic kidney disease (DKD), HR (95% CI) per 10% decrease in eGFRrediff
- 1.29 (1.26, 1.33)
- Diabetic neuropathy (DN), HR (95% CI) per 10% decrease in eGFRrediff
- 1.17 (1.12, 1.22)
- Overall DMCs, risk per SD decrease in eGFRabdiff
- 28% higher
- DR, risk per SD decrease in eGFRabdiff
- 14% higher
- DKD, risk per SD decrease in eGFRabdiff
- 56% higher
- DN, risk per SD decrease in eGFRabdiff
- 29% higher
- Incident DMCs
- 5,753
- Incident DR
- 2,752
- Incident DKD
- 3,203
- Incident DN
- 1,149
Observational data: associations, not effects.
Original publication
The Difference Between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate and Risk of Diabetic Microvascular Complications Among Adults With Diabetes: A Population-Based Cohort Study. Diabetes Care. Published 12 March 2024. doi:10.
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