Difference between cystatin C- and creatinine-based estimated glomerular filtration rate and risk of diabetes-related multimorbidity among adults with diabetes
Authors' conclusion
Lower eGFRdiff values were independently associated with elevated diabetes-related multimorbidity risks. These findings suggest that monitoring eGFRdiff in individuals with diabetes could aid in identifying patients with high-risk multimorbidity and potentially improve clinical outcomes.
Study context
- Population
- UK Biobank participants with diabetes, free of diabetes-related microvascular or macrovascular disease at baseline
- Participants
- 21,938 participants
- Exposure
- Per 10 mL/min/1.73 m² decrease in eGFRabdiff and per 10% decrease in eGFRrediff
- Outcome
- Incidence of any multimorbidity
- Follow-up
- Median 12.5 years
Methodological detailsUK Biobank, Cox proportional hazard regression
- UK Biobank
- Cox proportional hazard regression
Main finding
As reported in the abstract
Cases of any multimorbidity
2,252
Higher risk per 10 mL/min/1.73 m² decrease in eGFRabdiff
23 %
Observational data: associations, not effects.
Secondary outcomes
Microvascular-macrovascular multimorbidity · median follow-up 12.5 years
- Cases
- 1,554
- Higher risk per 10 mL/min/1.73 m² decrease in eGFRabdiff
- 22 %
Microvascular multimorbidity · median follow-up 12.5 years
- Cases
- 792
- Higher risk per 10 mL/min/1.73 m² decrease in eGFRabdiff
- 32 %
Macrovascular multimorbidity · median follow-up 12.5 years
- Cases
- 642
- Higher risk per 10 mL/min/1.73 m² decrease in eGFRabdiff
- 23 %
Subgroup analyses
- Subgroup analyses yielded consistent results
Original publication
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