High inflammatory burden may link non-albuminuric diabetic kidney disease to carotid atherosclerosis
Authors' conclusion
This study showed a higher inflammatory burden in DKD and particularly in NA-DKD. sTNF-R1 was associated with the presence of carotid atherosclerotic plaque, and this could partially explain the elevated cardiovascular risk associated with this phenotype.
Study context
- Population
- Adults with T2D, with or without diabetic kidney disease (DKD); carotid and kidney US, arterial stiffness and 37 inflammatory biomarkers measured
- Participants
- 132 / 48 / 46 / 44 / 42
- Exposure
- DKD vs T2D without DKD
- DKDn = 132
- Controlsn = 48reference
- A-DKDn = 46
- NA-DKDn = 44
- Albuminuric and low eGFR DKDn = 42
- Outcome
- Carotid plaque prevalence
Main finding
As reported in the abstract
P = 0.008
Observational data: associations, not effects.
Further findings
Pulse wave velocity · trend toward higher with DKD
P = 0.082
Carotid plaque by TNF-R1 top tertile, among DKD
| OR (95% CI) | P value | ||
|---|---|---|---|
| TNF-R1 top tertileQ value = 0.0494 · independently associated; adjusted for major confounders | 4.92 (1.41–17.18) | P = 0.010 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | DKD | Controls | P value |
|---|---|---|---|
| Renal resistive index | 0.75 ± 0.09 | 0.71 ± 0.08 | P = 0.016 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
High inflammatory burden may link non-albuminuric diabetic kidney disease to carotid atherosclerosis. Cardiovasc Diabetol. Published 30 March 2026. doi:10.
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