Cardiovascular risk and renal injury profile in subjects with type 2 diabetes and non-albuminuric diabetic kidney disease
Authors' conclusion
Our data showed a worse cardiovascular and renal injury profile in NA-DKD subjects. This finding emphasizes the central role of eGFR in the definition of cardiovascular risk profile of diabetic subjects together with albuminuria.
Study context
- Population
- Subjects with T2D stratified by estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR)
- Participants
- 160 subjects
- Exposure
- NA-DKD vs other diabetic kidney disease (DKD) phenotypes and controls
- Outcome
- Cardiovascular risk profile (PWV, RRI, carotid plaque)
Main finding
As reported in the abstract
- Characteristics similar in AL-DKD; A-DKD profile closer to controls
- NA-DKD vs Controls: P = 0.045
- NA-DKD vs Controls: P = 0.04
- NA-DKD vs Controls: P = 0.009
Observational data: associations, not effects.
Further findings
| Outcome | Controls | NA-DKD | P value |
|---|---|---|---|
| Urinary TreFoil Factor 3 (tubular damage)NA-DKD vs Controls · higher with NA-DKD | mean 1253.84 ± 682.17 ng/mL | mean 1533.14 ± 878.31 ng/mL | P = 0.047 |
Determinants of pulse wave velocity (PWV) and renal resistive index (RRI) (multiple regression)
- RRI as determinant of PWV, β
- 9.4 (P = 0.02)
- eGFR as influence on RRI, β
- - 0.01 (P = 0.01)
- Urinary osteopontin with PWV, β
- 2.6 (P = 0.049)
- Urinary osteopontin with RRI, β
- 0.09 (P = 0.006)
Original publication
Cardiovascular risk and renal injury profile in subjects with type 2 diabetes and non-albuminuric diabetic kidney disease. Cardiovasc Diabetol. Published 13 December 2023. doi:10.
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