Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project
Authors' conclusion
People with DKD, with reduced eGFR or both reduced eGFR and elevated UACR, but not with elevated UACR alone, are at higher CV risk. Personalizing therapy based on clinic-based renal phenotyping can facilitate the initiation of CV disease modifying therapy.
Study context
- Population
- People with diabetes mellitus (DM) (mean age 58 ± 18 years, 51.9% males)
- Participants
- 2,306 people
- Exposure
- Diabetic kidney disease (DKD) phenotypes vs no DKD
- Outcome
- Composite of cardiovascular (CV) events
- Follow-up
- Median 2.8 years (IQR 1.7; 4.0)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
CV events
Each group vs normal eGFR and UACRAdjusted hazard ratio (95% CI)
DKD
1.02(1.01–1.03)
Reduced eGFR
1.78(1.19–2.67)
Reduced eGFR and elevated UACR
1.60(1.08–2.37)
Elevated UACR only
0.91(0.62–1.32)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| SGLT2i and RAAS inhibitor prescriptionsDKDvs No DKDLess frequent with DKD | OR (SGLT2i prescription) 0.38 (95% CI 0.29–0.49) | P < 0.001 | |
| SGLT2i and RAAS inhibitor prescriptionsDKDvs No DKDLess frequent with DKD | OR (RAAS inhibitor prescription) 0.39 (95% CI 0.30–0.50) | P < 0.001 | |
| 0.20.5125Ratio (log scale) |
Original publication
Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project. Cardiovasc Diabetol. Published 30 July 2025. doi:10.
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