Metabolically “extremely unhealthy” obese and non-obese people with diabetes and the risk of cardiovascular adverse events: the Silesia Diabetes - Heart Project
Authors' conclusion
Both non-obese and obese people with DM and 3 associated CKM comorbidities represent an "extremely unhealthy" phenotype which are at the highest risk of CV adverse events. These results highlight the importance of risk stratification of people with DM for risk factor management utilising an interdisciplinary approach.
Study context
- Population
- People with diabetes mellitus (DM) enrolled in the prospective Silesia Diabetes Heart Project; median age 60 (IQR 45–70), 48.8% females
- Participants
- 2,105 people
- Exposure
- Obesity and number of cardiovascular-kidney-metabolic (CKM) comorbidities in people with DM
- Outcome
- Composite of:
- CV death
- Myocardial infarction (MI)
- New onset of heart failure (HF)
- Ischemic stroke
Main finding
As reported in the abstract
Primary composite outcome
Adjusted hazard ratio (95% CI)
Group 1
4.50(1.20–16.88)
Group 6
3.78(1.06–13.47)
Observational data: associations, not effects.
Further findings
Interaction: obese vs non-obese in "extremely unhealthy" persons
- Impact of CKM comorbidities consistent in obese and non-obese
- Pint=0.824
Interaction: age <65 years vs older adults
- Impact of CKM comorbidities more pronounced in individuals aged < 65 years than older adults
- Pint= 0.028
Original publication
Metabolically “extremely unhealthy” obese and non-obese people with diabetes and the risk of cardiovascular adverse events: the Silesia Diabetes - Heart Project. Cardiovasc Diabetol. Published 3 September 2024. doi:10.
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