Insulin Pump Use and Diabetic Ketoacidosis Risk in Type 1 Diabetes: Secular Trends over Four Decades
Authors' conclusion
DKA risk associated with CSII in type 1 diabetes has declined substantially since the 1980s such that the remaining risk in the past decade appears to be of low magnitude.
Study context
- Population
- Participants with T1D in the DCCT/EDIC study, 1983–2017
- Participants
- 1,441 participants
- Exposure
- Time-varying continuous subcutaneous insulin infusion (CSII) use vs no CSII use
- Outcome
- Diabetic ketoacidosis (DKA) events, overall and by decade
- Follow-up
- 1983 to 2017
Methodological detailsDCCT/EDIC participants, time-varying exposure, crude and adjusted Cox proportional hazards models
- DCCT/EDIC participants
- Time-varying exposure
- Crude and adjusted Cox proportional hazards models
Main finding
As reported in the abstract
DKA risk by decade
CSII vs No CSIIAdjusted hazard ratio (95% CI)P value
1980s
5.81(3.28–10.29)
P < 0.0012010s; not significantly elevated
1.24(0.73–2.12)
P = 0.43Observational data: associations, not effects.
Original publication
Insulin Pump Use and Diabetic Ketoacidosis Risk in Type 1 Diabetes: Secular Trends over Four Decades. Diabetes Technol Ther. Published 10 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →