Does faster aspart improve time in range in children with type 1 diabetes with glycaemia close to target on insulin pump therapy?
Primary result · TIR (3.9-10.0 mmol/L)Result — go to the resultMean difference −0.9 % 95% CI −2.60 to 0.86Authors' conclusion
In this randomised crossover study of children and adolescents with T1D achieving glycaemia close to target on CSII, switching from SIA to FIA does not improve TIR.
Study context
- Population
- Children and adolescents aged 6–17 years with T1D duration ≥1 year, continuous subcutaneous insulin infusion (CSII) use ≥3 months, continuous glucose monitoring (CGM) use ≥1 month and HbA1c 64 mmol/mol (<8%), achieving glycaemia close to target; mean T1D duration ≈7 years, 66% male, mean HbA1c 53 mmol/mol, 7%enrolled
- Participants
- 77 children
- Comparison
- Faster insulin aspart vs standard insulin aspart on CSII
- Primary endpoint
- Between-treatment difference in time in range (TIR) (3.9-10.0 mmol/L, 70-180 mg/dL)
- Follow-up
- End of each treatment phase
Methodological detailsprospective, open-label, 2-week run-in, All participants used the same CGM system; 4 weeks per insulin
- Prospective
- Open-label
- 2-week run-in
- All participants used the same CGM system; 4 weeks per insulin
Primary result
TIR (3.9-10.0 mmol/L)
Mean difference
−0.9 %
95% CI −2.60 to 0.86
P = 0.322
By group
FIAvs SIA
mean difference −0.9 % (95% CI −2.60 to 0.86); P = 0.322
As reported in the abstract
Further findings
Time in tight range
P = 0.674
Time in tight range
- Time in tight range similar between treatments
Additional glycaemic metrics
- Similar patterns were observed for additional glycaemic metrics
Original publication
Does faster aspart improve time in range in children with type 1 diabetes with glycaemia close to target on insulin pump therapy? Diabet Med. Published 12 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →