Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery
Primary result · Postprandial glucose excursionResult — go to the resultDifference in excursion −3.8 mg/dL 95% CI −5.8 to −1.7Authors' conclusion
Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets.
Study context
- Population
- Youth aged 10–18 years with T1D using AID; mean age 15.0 ± 1.7 years, 47% male, mean HbA1c 7.5% ± 0.9%crossover
- Participants
- 30 participants
- Comparison
- Faster insulin aspart vs standard insulin aspart with AID
Methodological detailsdouble-blind
- Double-blind
Primary result
Postprandial glucose excursion · 4 weeks
Difference in excursion
−3.8 mg/dL
95% CI −5.8 to −1.7
P < 0.001
FIAvs SIA
difference in excursion −3.8 mg/dL (95% CI −5.8 to −1.7); P < 0.001
As reported in the abstract
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Postprandial TITR (70-140 mg/dL) | increase in mean TITR 1.9 % | P = 0.02 |
| Postprandial iAUCLower with FIA | decrease in mean iAUC 2.0 mg/dL | P = 0.003 |
Subgroups
- Differences most noticeable for breakfast, meals with >45 g carbohydrates and participants with lower insulin-to-carbohydrate ratios
Original publication
Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery. Diabetes Obes Metab. Published 27 January 2025. doi:10.
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