A Comparison of Faster Insulin Aspart with Standard Insulin Aspart Using Hybrid Automated Insulin Delivery System in Active Children and Adolescents with Type 1 Diabetes: A Randomized Double-Blind Crossover Trial
Primary result · Time above rangeResult — go to the resultMean difference −0.9 % 95% CI −2.4% to 0.6%Authors' conclusion
FIA was not superior to SIA with hybrid AID system use in physically active children and adolescents with type 1 diabetes. Nonetheless, both insulin formulations enabled high overall TIR and low time above and below ranges, even during and after documented exercise.
Study context
- Population
- Active children and adolescents with T1D (16 females; age 15.0 ± 1.7 years; baseline HbA1c 7.5% ± 0.9%), encouraged to exercisecrossover
- Participants
- 30 children
- Comparison
- Faster insulin aspart vs standard insulin aspart with hybrid automated insulin delivery (AID)
- Primary endpoint
- % sensor glucose time above range (180 mg/dL [10.0 mmol/L]) by CGM
- Follow-up
- 4-week periods
Methodological detailsdouble-blind, multinational, crossover
- Double-blind
- Multinational
- Crossover
Primary result
Time above range
Mean difference
−0.9 %
95% CI −2.4% to 0.6%
P = 0.23
By group
FIAvs SIA
mean difference −0.9 % (95% CI −2.4% to 0.6%); P = 0.23
As reported in the abstract
Further findings
TIR
Time below range
Time in range (TIR)
- No difference in mean TIR
Time below range
- No difference in median time below range
Glycemic outcomes during exercise or postprandial periods
- Comparable for the two treatment arms
Safety
- No severe hypoglycemia or DKA events occurred
Original publication
A Comparison of Faster Insulin Aspart with Standard Insulin Aspart Using Hybrid Automated Insulin Delivery System in Active Children and Adolescents with Type 1 Diabetes: A Randomized Double-Blind Crossover Trial. Diabetes Technol Ther. Published 22 August 2023. doi:10.
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