A Pilot Study Evaluating Meal Timing, Macronutrient Composition, and Faster-Acting Insulin Aspart Versus Insulin Aspart on Postprandial Glycemia with the Medtronic Advanced Hybrid Closed-Loop System
Main finding · Postmeal TIR, all meal types, timing and bolus conditions combinedResult — go to the resultMean difference 5.17 % CI −0.09 to 10.43Authors' conclusion
For adults with type 1 diabetes who are susceptible to morning hyperglycemia, FiAsp delivered by AHCL and higher fat content of meals may help improve postprandial glycemic outcomes.
Study context
- Population
- Adults with T1D on MiniMed 780G advanced hybrid closed loop (AHCL); mean (SD) age 48 (13) years, 58% male, HbA1c 6.7 (0.7)%/50 (7) mmol/mol
- Participants
- 12 adults
- Comparison
- FiAsp vs insulin aspart delivered by AHCL
- Outcome
- CGM %TIR (3.9-10.0 mmol/L) postmeal, FiAsp vs insulin aspart
- Follow-up
- 4 h postmeal
Methodological detailssequential crossover, standardized test meals, 11 weeks of each insulin in sequence; 12 standardized meals per period (60 g carbohydrate; HFLP, HFHP, LFLP; morning and evening; full or 50% reduced bolus)
- Sequential crossover
- Standardized test meals
- 11 weeks of each insulin in sequence; 12 standardized meals per period (60 g carbohydrate; HFLP, HFHP, LFLP; morning and evening; full or 50% reduced bolus)
Main finding
As reported in the abstract
Postmeal TIR, all meal types, timing and bolus conditions combined
Mean difference
5.17 %
CI −0.09 to 10.43
P = 0.054
FiAspvs Insulin aspart
mean difference 5.17 % (CI −0.09 to 10.43); P = 0.054
Further findings
Mean
| Outcome | HFLP | HFHP | LFLP | P value |
|---|---|---|---|---|
| Postmeal TIR by meal compositionBetween HFLP and LFLP · across HFLP, HFHP and LFLP | 83.7% (SD 19.6) | 74.7% (SD 26.9) | 62.0% (SD 23.1) | P < 0.01 |
Insulin formulation effect by full vs 50% premeal bolus or meal composition
- Insulin formulation did not impact outcomes with full vs 50% premeal bolus or meal composition
Original publication
A Pilot Study Evaluating Meal Timing, Macronutrient Composition, and Faster-Acting Insulin Aspart Versus Insulin Aspart on Postprandial Glycemia with the Medtronic Advanced Hybrid Closed-Loop System. Diabetes Technol Ther. Published 28 July 2025. doi:10.
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