Long-Term Improvements in Glycemia and User-Reported Outcomes Associated with Open-Source Automated Insulin Delivery Systems in Adults with Type 1 Diabetes in the United Kingdom: A Real-World Observational Study
Authors' conclusion
The use of OS-AID is associated with long-term improvements in HbA1c, hypoglycemia awareness, and diabetes-related distress in type 1 diabetes. These benefits were achieved without increased rates of hospital admissions, diabetic ketoacidosis, or severe hypoglycemia.
Study context
- Population
- Adults with T1D who commenced open-source AID (OS-AID) May 2016–April 2021, 12 UK centres; 51.9% male, 90.1% White British, mean age 41.4 years, median diabetes duration 25 years (IQR 17–32)
- Participants
- 81 OS-AID users
- Exposure
- OS-AID use: follow-up vs baseline
- Outcome
- HbA1c
- Follow-up
- Mean 1.7 years
Methodological detailsmulticentre, before-after (baseline vs follow-up), Anonymized routine clinical data (December 2019–November 2023) submitted to a secure web-based tool within the NHS network
- Multicentre
- Before-after (baseline vs follow-up)
- Anonymized routine clinical data (December 2019–November 2023) submitted to a secure web-based tool within the NHS network
Main finding
As reported in the abstract
Reduction
0.8 % (9 mmol/mol)
P < 0.001
By group
Observational data: associations, not effects.
Further findings
Impaired hypoglycemia awareness (Gold score ≥4)
P = 0.039
Individuals achieving hemoglobin A1c (HbA1c) ≤ 7.0% (53 mmol/mol) · mean follow-up 1.7 years
- Percentage achieving HbA1c ≤ 7.0% increased (P < 0.001)
- from 48.6% to 75.7%
Diabetes-related distress score
- Reduction in diabetes-related distress score
- 0.9 (95% CI −0.3, −1.5; P = 0.006)
Gold score (hypoglycemia awareness)
- Reduction in Gold score
- 0.7 (95% CI −0.1, −1.3; P = 0.022)
User opinion of OS-AID
- Of those asked, all participants stated OS-AID had a positive impact on quality of life
Safety
- The number of hospital admissions was low
Original publication
Long-Term Improvements in Glycemia and User-Reported Outcomes Associated with Open-Source Automated Insulin Delivery Systems in Adults with Type 1 Diabetes in the United Kingdom: A Real-World Observational Study. Diabetes Technol Ther. Published 27 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →