Glycemic Control Across the Menstrual Cycle in Women with Type 1 Diabetes Using the MiniMed 780G Advanced Hybrid Closed-Loop System: The 780MENS Prospective Study
Authors' conclusion
Our results suggest that differences in glycemic control may be found across the menstrual cycle in women with T1D using the MiniMed™ 780G AHCL. Although higher average glucose levels may be expected in the late luteal phase, the deterioration of glycemic control during this phase may be mild with the MiniMed™ 780G AHCL, given the similarities for most of the CGM metrics with respect to the early follicular phase.
Study context
- Population
- Women with T1D using the MiniMed 780G advanced hybrid closed-loop (AHCL) system36 cycles
- Participants
- 12 women
- Exposure
- Late luteal phase vs early follicular phase
- Outcome
- Glycemic control (CGM and insulin delivery metrics) across 2 menstrual cycle phases
Methodological detailswithin-participant comparison across 3 consecutive menstrual cycles, mixed models
- Within-participant comparison across 3 consecutive menstrual cycles
- Mixed models
Main finding
As reported in the abstract
Average glucose
P = 0.002
Observational data: associations, not effects.
Further findings
Total daily insulin dose · increase in late luteal phase
P < 0.001
TIR
P = 0.101
TIR
- Similar values between phases for most remaining continuous glucose monitoring (CGM) metrics
Original publication
Glycemic Control Across the Menstrual Cycle in Women with Type 1 Diabetes Using the MiniMed 780G Advanced Hybrid Closed-Loop System: The 780MENS Prospective Study. Diabetes Technol Ther. Published 16 January 2025. doi:10.
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