A Comparison of Glucose and Additional Signals for Three Different Exercise Types in Adolescents with Type 1 Diabetes Using a Hybrid Closed-Loop System
Authors' conclusion
HCL use in adolescents with T1D results in excellent TIR during different forms of exercise when a temporary target is set 2 h before.
Study context
- Population
- Adolescents with T1D using hybrid closed-loop (HCL) (Medtronic MiniMed 670G); average age 16.3 ± 2.1 years, 50% females, T1D duration 9.4 ± 4 years; temporary glucose target 8.3 mmol/L set 2 h prior and during exercise
- Participants
- 28 adolescents
- Comparison
- Moderate-intensity exercise (MIE) vs HIE vs resistance exercise (RE) during HCL use
- Outcome
- TIR 3.9-10 mmol/L (70-180 mg/dL)
- Follow-up
- 14 h from exercise onset
Main finding
As reported in the abstract
TIR
P = 0.012
Further findings
Median, %
| Outcome | HIE | MIE | P value |
|---|---|---|---|
| TAR · 14 h from exercise onsetMIE vs HIE · TAR greater with MIE | 6.9 (IQR 0.0–14) | 18 (IQR 2.4–28) | P = 0.041 |
- Lactate, GH, noradrenaline and heart rate · during exercise · HIE and RE vs MIE · higher lactate
- P = 0.001
- Lactate, GH, noradrenaline and heart rate · during exercise · HIE and RE vs MIE · higher GH
- P = 0.001
- Lactate, GH, noradrenaline and heart rate · during exercise · HIE and RE vs MIE · higher noradrenaline
- P = 0.001
- Lactate, GH, noradrenaline and heart rate · during exercise · HIE and RE vs MIE · higher heart rate
- P = 0.01
Safety
Hypoglycemia · majority following the meal after exercise
Original publication
A Comparison of Glucose and Additional Signals for Three Different Exercise Types in Adolescents with Type 1 Diabetes Using a Hybrid Closed-Loop System. Diabetes Technol Ther. Published 9 January 2025. doi:10.
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