Temporary Target Versus Suspended Insulin Infusion in Patients with Type 1 Diabetes Using the MiniMed 780G Advanced Closed-Loop Hybrid System During Aerobic Exercise: A Randomized Crossover Clinical Trial
Authors' conclusion
Our data appear to show that the use of TT compared with SII is equally safe in all phases of AE. However, the use of TT allows for a better glycemic profile in the early phase of exercise.
Study context
- Population
- Adults with T1D using advanced hybrid closed-loop systems (MiniMed 780G), two moderate-intensity aerobic exercise sessions; age 44.6 ± 13.8 years; basal TIR 79.4 ± 12%analysed
- Participants
- 33 adults
- Comparison
- Temporary target (TT) vs suspension of insulin infusion (SII) during aerobic exercise
- Primary endpoint
- Safety: hypoglycemic events and CGM metrics during aerobic exercise
- Follow-up
- Immediate (baseline to 59 min), early (60 min to 6 h) and late (6 to 36 h) post-exercise phases
Primary result
As reported in the abstract
Hypoglycemic events, %TBR <70 mg/dL and %TBR <54 mg/dL
- No difference in number of hypoglycemic events, %TBR <70 mg/dL and %TBR <54 mg/dL between TT and SII
Further findings
%TIR 70-180 mg/dL, early phase · early phase (60 min to 6 h) · better with TT
P = 0.005
%TITR 70-140 mg/dL, early phase · early phase (60 min to 6 h) · better with TT
P = 0.04
%TAR >180 mg/dL, early phase · early phase (60 min to 6 h) · better with TT
P = 0.01
%TIR, diurnal period · better with TT
P = 0.02
%TAR, diurnal period · better with TT
P = 0.04
Continuous glucose monitoring (CGM) metrics during phases of aerobic exercise
- No significant differences in CGM metrics during the different phases of aerobic exercise (AE)
Safety
- No difference in number of hypoglycemic events between TT and SII
Original publication
Temporary Target Versus Suspended Insulin Infusion in Patients with Type 1 Diabetes Using the MiniMed 780G Advanced Closed-Loop Hybrid System During Aerobic Exercise: A Randomized Crossover Clinical Trial. Diabetes Technol Ther. Published 30 September 2024. doi:10.
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