Continuous Glucose Monitoring With Geriatric Principles in Older Adults With Type 1 Diabetes and Hypoglycemia: A Randomized Controlled Trial
Primary result · Change in hypoglycemia (time <70 mg/dL)Result — go to the resultMedian difference −2.3% 95% CI −3.7% to −1.3%Authors' conclusion
In older adults with T1D and high risk of hypoglycemia, CGM use enhanced by geriatric principles can lower hypoglycemia without worsening glycemic control in a cost-effective fashion.
Study context
- Population
- Older adults (≥65 years) with T1D and hypoglycemia (≥2 episodes of blood glucose <70 mg/dL for ≥20 min over 2 weeks), continuous glucose monitoring (CGM) naive or CGM users; aged 71 ± 5 years, 21% ≥75 yearsrandomized
- Participants
- 131 adults
- Comparison
- CGM with geriatric principles vs usual care
- Interventionn = 68
- Controln = 63reference
- Primary endpoint
- Change in time with blood glucose <70 mg/dL
- Follow-up
- Baseline to 6 months
Primary result
Change in hypoglycemia (time <70 mg/dL)
Median difference
−2.3%
95% CI −3.7% to −1.3%
P < 0.001
Change by group
Intervention
−2.6%
median
Control
−0.3%
median
Interventionvs Control
median difference −2.3% (95% CI −3.7% to −1.3%); P < 0.001
As reported in the abstract
Further findings
Change in hypoglycemia, subgroups by prior CGM use · baseline to 6 months
- CGM naive
- −2.8% (95% CI −5.6%, −0.8%)
- CGM users
- −1.2% (95% CI −2.7%, −0.1%)
HbA1c
- HbA1c did not differ between the groups
Cost-effectiveness (health care sector perspective)
- Incremental cost-effectiveness ratio, intervention
- $71,623 per quality adjusted life-year
Original publication
Continuous Glucose Monitoring With Geriatric Principles in Older Adults With Type 1 Diabetes and Hypoglycemia: A Randomized Controlled Trial. Diabetes Care. Published 26 September 2024. doi:10.
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