Performance of the MiniMed 780 G system on mitigating menstrual cycle‐dependent glycaemic variability
Authors' conclusion
The fully automated adaptive algorithm of the MiniMed 780G system mitigated menstrual cycle-dependent glycaemic variability, successfully attaining the recommended glycaemic outcomes with a TIR greater than 70% throughout the entire menstrual cycle.
Study context
- Population
- Adolescent and young adult females with T1D and regular spontaneous menstruation
- Participants
- 15 participants
- Comparison
- Luteal vs follicular phase, during open loop period (OLP) and advanced hybrid closed-loop (AHCL) period with MiniMed 780G
- Outcome
- Mean TIR during OLP
- Follow-up
- 3 months
Methodological detailswithin-patient comparison of OLP and AHCL periods, Each period (OLP and AHCL) lasted 3 consecutive months
- Within-patient comparison of OLP and AHCL periods
- Each period (OLP and AHCL) lasted 3 consecutive months
Main finding
As reported in the abstract
P < 0.01
Further findings
| Outcome | Luteal phase | Follicular phase | P value |
|---|---|---|---|
| Mean TAR during OLPTAR significantly increased in luteal phase | mean 24.87% ± 2.97% | mean 21.07% ± 2.58% | P < 0.01 |
- Time in range (TIR) during AHCL period
- P = 0.72
TIR during AHCL period
- TIR comparable during both phases
Auto basal and Auto correction insulin during AHCL period
- Increase in Auto basal during luteal phase
- 13.55%
- Increase in Auto correction during luteal phase
- 30.6%
- P value
- P < 0.01
Safety
Time below 70 mg/dL during AHCL period
- TIR comparable without increasing time below 70 mg/dL
- P > 0.05
Original publication
Performance of the MiniMed 780 G system on mitigating menstrual cycle‐dependent glycaemic variability. Diabetes Obes Metab. Published 9 September 2024. doi:10.
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