Clinical Features and Human Leukocyte Antigen (HLA) Genetics Differ in Children at Type 1 Diabetes Onset by Hispanic Ethnicity
Authors' conclusion
Hispanic White children developing type 1 diabetes have a high prevalence of HLA DR4-DQ8, which can be utilized to select individuals for immune monitoring with islet autoantibodies to lessen diabetic ketoacidosis and potentially prevent diabetes onset.
Study context
- Population
- Children diagnosed with T1D (≤20 years old) and tested for islet autoantibodies within 1 year of diagnosis
- Participants
- 1,297 children
- Exposure
- Hispanic White vs non-Hispanic White children at T1D diagnosis
- Hispanic White (HW)n = 398
- Non-Hispanic White (NHW)n = 899reference
- Outcome
- Age at diabetes onset
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
DKA at diagnosis · more with HW
P < 0.001
DR4-DQ8 haplotype prevalence (HLA-typed children, n = 637) · higher with HW
P < 0.001
- DR4-DQ8 haplotype prevalence (HLA-typed children, n = 637) — DR4-DQ8 frequency in HW vs reference Hispanic population, OR
- 6.5 (95% CI 4.6-9.3)
Sex, A1c, number and prevalence of islet autoantibodies
- No difference between the 2 cohorts
Original publication
Clinical Features and HLA Genetics Differ in Children at Type 1 Diabetes Onset by Hispanic Ethnicity. J Clin Endocrinol Metab. Published 4 September 2024. doi:10.
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