Open-source automated insulin delivery shows comparable glycemic outcomes to a commercial hybrid closed-loop system in real-world type 1 pediatric diabetes care: a retrospective cohort study from British Columbia, Canada
Authors' conclusion
Open-source automated insulin delivery systems demonstrated similar long-term glycemic outcomes and safety compared with hybrid closed-loop systems
Study context
- Population
- Youth aged ≤19 years with T1D for ≥1 year using a system for ≥6 months, January 2015–June 2024, British Columbia, Canada; mean age 13.8 years, 57% male
- Participants
- 198 participants
- Exposure
- Open-source AID vs hybrid closed-loop systems
- Open-source AIDn = 143
- Hybrid closed-loopn = 55reference
- Outcome
- HbA1c
- Follow-up
- Baseline to 18 months
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Open-source AID
7.40% to 6.96%
HCL
7.35% to 7.28%
Observational data: associations, not effects.
Further findings
GMI and TIR · across follow-up
- No significant differences in GMI or TIR between groups (adjusted analyses)
Safety
- Severe hypoglycaemia and DKA — Open-source AID
- 1 events
- Severe hypoglycaemia and DKA — DKA events
- 0
- Severe hypoglycaemia and DKA: HCL 1 events
Original publication
Open-source automated insulin delivery shows comparable glycemic outcomes to a commercial hybrid closed-loop system in real-world type 1 pediatric diabetes care: a retrospective cohort study from British Columbia, Canada. Pediatr Diabetes. Published 8 September 2026. doi:10.
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