Continuous glucose monitoring using the FreeStyle Libre Pro iQ in presymptomatic type 1 diabetes
Authors' conclusion
These findings support CGM as a promising tool for staging and risk stratification in early-stage type 1 diabetes, while highlighting the need for system-specific interpretation before use in therapeutic decision-making.
Study context
- Population
- Children and adolescents without islet autoantibodies or with early-stage (stage 1 or 2) T1D, December 2023 to December 2025; median age 10.0 years (IQR 7.9–12.8), 73 female among analysed126 analysed
- Participants
- 50 / 45 / 25
- Comparison
- FreeStyle Libre Pro iQ continuous glucose monitoring (CGM) in control, stage 1 and stage 2 type 1 diabetes; comparison with Dexcom G6
- Controln = 50reference
- Stage 1n = 45
- Stage 2n = 25
- Outcome
- ≥1 CGM parameter exceeding 97.5th percentile of control values
Methodological detailsCGM data unavailable or incomplete for 13 participants (9%)
- CGM data unavailable or incomplete for 13 participants (9%)
Performance
As reported in the abstract
P = 0.017
Further findings
| Outcome | Stage 1 | Stage 2 | P value |
|---|---|---|---|
| ≥2 CGM parameters exceeding 97.5th percentile thresholdStage 2 vs Stage 1 | 13% | 44% | P = 0.0077 |
| TA140 >15% (97.5th percentile threshold) | 0 events | 40% |
- TA140 >15% (97.5th percentile threshold) — Progressed to clinical diabetes within 1 year exceeding TA140 threshold (rapid progressors)
- 6 of 8
- Sensitivity for progression to clinical diabetes within 1 year (97.5th percentile of control values): FreeStyle Libre Pro iQ 75% to 100% · sensitivity 75% to 100%
- Sensitivity for progression to clinical diabetes within 1 year (97.5th percentile of control values): Dexcom G6 50% to 100% · sensitivity 50% to 100%
Sensitivity for progression to clinical diabetes within 1 year (97.5th percentile of control values)
- FreeStyle Libre Pro iQ values differed markedly from those previously observed with Dexcom G6 in a similar cohort
Original publication
Continuous glucose monitoring using the FreeStyle Libre Pro iQ in presymptomatic type 1 diabetes. Diabetologia. Published 7 September 2026. doi:10.
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