Discrimination and Precision of Continuous Glucose Monitoring in Staging Children With Presymptomatic Type 1 Diabetes
Authors' conclusion
This study demonstrated the potential of integrating CGM into staging and monitoring of early-stage type 1 diabetes. However, substantial improvement in the precision of CGM is required for its application in routine monitoring practices.
Study context
- Population
- Children and adolescents in public health screening for islet autoantibodies in Bavaria, Germany; Continuous glucose monitoring (CGM) with Dexcom G6; 57 female, median age 10 (range 3–17) yearsvalid data from 97
- Participants
- 118 children
- Comparison
- CGM in islet autoantibody-negative controls vs stage 1 and stage 2 presymptomatic T1D
- Controlsn = 33reference
- Stage 1n = 46
- Stage 2n = 18
- Outcome
- Ability of CGM to differentiate islet autoantibody-negative controls from early-stage T1D
Performance
As reported in the abstract
CGM discrimination (thresholds at 100% specificity in controls)
| Test or model | Value | >10% of glucose values above 140 mg/dL (TA140) | Identified by elevations in any 2 parameters |
|---|---|---|---|
| Controls | median 115.3 (IQR 106.8–124.4) mg/dL | 11 (33%) | |
| Stage 2 | 12 (67%) |
Value
Controlsmedian 115.3 (IQR 106.8–124.4) mg/dL
Stage 2— not stated in the abstract
>10% of glucose values above 140 mg/dL (TA140)
Controls11 (33%)
Stage 2— not stated in the abstract
Identified by elevations in any 2 parameters
Controls— not stated in the abstract
Stage 212 (67%)
Further findings
Prediction of progression to clinical diabetes within 1 year (elevations in any 2 parameters)
- Participants who developed clinical diabetes identified
- 9 (82%) of 11
Consistency of a second CGM
- Poor consistency in a second CGM
- 18 participants
Original publication
Discrimination and Precision of Continuous Glucose Monitoring in Staging Children With Presymptomatic Type 1 Diabetes. J Clin Endocrinol Metab. Published 16 October 2024. doi:10.
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