Impact of Hybrid Continuous Glucose Monitoring on Glycemic Control in a Medical Intensive Care Unit
Authors' conclusion
In this prospective MICU cohort, real-time hybrid CGM use improved glycemic control and reduced severe hyperglycemia without increasing hypoglycemia
Study context
- Population
- Medical intensive care unit (ICU) patients receiving continuous intravenous (IV) insulinmatched historical controls
- Participants
- 100 vs 100
- Exposure
- Nurse-driven hybrid continuous glucose monitoring (CGM)+point-of-care (POC) protocol vs standard POC monitoring alone
- CGM+POCn = 100
- Controlsn = 100reference
- Outcome
- % time in glucose range (70-180 mg/dL), calculated using POC values (at least every 4 h)
- Follow-up
- During continuous IV insulin therapy
Methodological detailssingle-center, matched historical controls, 3590 temporally matched CGM-POC pairs available for analysis
- Single-center
- Matched historical controls
- 3590 temporally matched CGM-POC pairs available for analysis
Main finding
As reported in the abstract
Time in range (70-180 mg/dL)
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
%
| Outcome | Controls | P value |
|---|---|---|
| % time >250 mg/dLCGM vs Controls | 17 (SD 18) | P < 0.001 |
| % time >300 mg/dLCGM vs Controls | 11.3 (SD 1.4) | P < 0.001 |
- % time >250 mg/dL: CGM 6 (SD 11) %
- % time >300 mg/dL: CGM 2.7 (SD 0.6) %
Safety
Hypoglycemia
- Hypoglycemic events were infrequent and similar between groups
Original publication
Impact of Hybrid Continuous Glucose Monitoring on Glycemic Control in a Medical Intensive Care Unit. Endocr Pract. Published 4 September 2026. doi:10.
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