Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxia Conditions: A Randomized Controlled Trial—FOX Study
Authors' conclusion
Both CGM systems showed reduced accuracy under hypoxia, particularly during dynamic glycemic changes.
Study context
- Population
- Healthy volunteers and participants with diabetes exposed to normobaric hypoxia, with a standardized mixed meal and moderate-intensity cycling exercise; median age 29.5 years; with diabetes: 53% T1D, 47% T2D15 healthy, 15 with diabetes
- Participants
- 30 volunteers
- Comparison
- FreeStyle Libre vs Dexcom G6 continuous glucose monitoring (CGM) accuracy vs venous plasma glucose during hypoxia
- Primary endpoint
- Mean absolute relative difference (MARD) of CGM values vs reference venous plasma glucose (hexokinase method)
- Follow-up
- During hypoxia
Methodological detailsstandardized normobaric hypoxia (FiO2 14.5%), simultaneous wear of both sensors
- Standardized normobaric hypoxia (FiO2 14.5%)
- Simultaneous wear of both sensors
Primary result
As reported in the abstract
MARD, healthy volunteers
Further findings
MARD, participants with diabetes · during hypoxia
CEGA: readings in zones A or B · during hypoxia
Original publication
Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxia Conditions: A Randomized Controlled Trial—FOX Study. Diabetes Technol Ther. Published 17 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →