Glycometabolic outcomes in adult type 1 diabetic patients switching to closed-loop systems
Authors' conclusion
AID-naïve T1D patients switching to HCL/AHCL systems have significantly and safely improved their glycometabolic outcomes with their high satisfaction with the new type of treatment.
Study context
- Population
- Automated Insulin Delivery (AID)-naïve adults with T1D aged 19–65 years managed with MDI or Continuous Subcutaneous Insulin Infusion (CSII) in open-loop
- Participants
- 54 adults
- Exposure
- Switch to Hybrid Closed Loop (HCL)/Advanced Hybrid Closed Loop (AHCL) systems
- HCL/AHCLn = 54
- Outcome
- TIR 70-180 mg/dL (3.9-10 mmol/L)
- Follow-up
- Baseline to 12 months
Methodological detailstwo-centre, 12-month
- Two-centre
- 12-month
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| TAR 180-250 mg/dL (10-13.9 mmol/L) · baseline to 12 months12 months vs Baseline · decreased | Baseline 30.6 ± 9.0 % · 12 months 19.3 ± 5.3 % | P < 0.001 for both |
| TAR ≥250 mg/dL (13.9 mmol/L) · baseline to 12 months12 months vs Baseline · decreased | Baseline 14.2 ± 10.2 · 12 months 4.8 ± 3.3 % | P < 0.001 for both |
| Glucose CV · baseline to end of studyEnd of study vs Baseline · decreased | Baseline 35.9 ± 7.8 % · End of study 33.0 ± 5.3 % | P < 0.05 |
Satisfaction with new technology
- Satisfaction with the new technology was scored as high
Safety
TBR 54-69 mg/dL (3-3.8 mmol/L) · baseline to end of study · decreased
P < 0.001 for both
TBR <54 mg/dL (3.0 mmol/L) · baseline to end of study · decreased
P < 0.001 for both
Original publication
Glycometabolic outcomes in adult type 1 diabetic patients switching to closed-loop systems. Diabetes Res Clin Pract. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →