The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Authors' conclusion
In people with type 1 diabetes, SBP and DBP variability are associated with kidney disease progression.
Study context
- Population
- People with T1D and baseline eGFR >45 ml/min per 1.73m2 attending two university hospital clinics, 2004–2018; median age 36 (range 18–85) years; 50% female; 78.5% White, 10.9% African Caribbean, 4.5% Asian, 6.1% Other
- Participants
- 3,079 people
- Exposure
- Blood pressure variability (BPV) and ethnicity as risk factors for kidney disease progression
- Outcome
- eGFR decline of ≥50% from baseline with final eGFR <30 ml/min per 1.73m2, with death as a competing risk
Methodological detailstwo university hospital clinics, competing-risk analysis (death), BPV assessed by visit-adjusted SD, CV and average real variability (ARV) for systolic blood pressure (SBP) and diastolic blood pressure (DBP)
- Two university hospital clinics
- Competing-risk analysis (death)
- BPV assessed by visit-adjusted SD, CV and average real variability (ARV) for SBP and DBP
Main finding
As reported in the abstract
14 year period
Reached the primary endpoint
272
8.8%
ARV of SBP (strongest association), HR
1.54
95% CI 1.27, 1.87p<0.001
Observational data: associations, not effects.
Original publication
The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes. Diabetologia. Published 1 April 2026. doi:10.
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