Diabetes complications

Smartphone-based App to Assess Diabetic Peripheral Neuropathy

J Diabetes Sci TechnolPublished Diagnostic accuracy study

Authors' conclusion

We present a clinically relevant, patient-operated smartphone application for large-fiber sensory monitoring, tested on patients with varying DPN risk. This novel platform has the potential to provide a precise, reliable, and accessible avenue for identifying individuals at risk of developing DPN complications, prior to overt clinical manifestation.

Study context

Population
Patients with pre-diabetes or diabetes
Participants
71 patients
Comparison
Smartphone-based vibration perception threshold (SVPT) vs Rydel-Seiffer tuning fork (RSTF)
Outcome
Correlation of SVPT with RSTF scores

Performance

As reported in the abstract

SVPT moderately correlated with RSTF scores (Rs)

−0.43

p = 0.0019

Further findings

SVPT vs clinical markers (hemoglobin A1c (HbA1c), age, disease duration), multivariable linear regression, adults aged 50 to 69 years

Model fit
F(4, 29) = 4.76, p = 0.00447, Multiple R2 = 0.396, Adjusted R2 = 0.313, ϵ = 0.167
Age × HbA1c interaction, positively associated with SVPT
β = 0.118, p = 0.001
Diabetes duration, negatively associated with SVPT
β = −0.098, p = 0.003

Original publication

Smartphone-based App to Assess Diabetic Peripheral Neuropathy. J Diabetes Sci Technol. Published 1 April 2026. doi:10.1177/19322968261426385

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