Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease
Authors' conclusion
DPN was an independent risk marker for dementia in T2D and cerebrovascular disease in both T1D and T2D
Study context
- Population
- Individuals with T1D and T2D without prior dementia or cerebrovascular disease and with vibration perception threshold (VPT) measurements, Steno Diabetes Center Copenhagen and Danish National Health Registries, 1998–20205,641 T1D
- Exposure
- Diabetic peripheral neuropathy (DPN) vs no DPN
- Outcome
- Incident dementia and cerebrovascular disease
Methodological detailsPoisson regression, stratified by diabetes type
- Poisson regression
- Stratified by diabetes type
Main finding
As reported in the abstract
DPN vs No DPNIncidence rate ratio (95% CI)
T1D: cerebrovascular disease
1.45(1.11–1.91)
T1D: dementia
1.61(0.75–3.48)
T2D: dementia
4.36(2.07–9.16)
T2D: cerebrovascular disease
1.45(1.18–1.80)
Observational data: associations, not effects.
Further findings
Cerebrovascular disease in T1D, additional adjustment for retinopathy and nephropathy
- Additional adjustment for retinopathy and nephropathy only attenuated the IRR for cerebrovascular disease in T1D (95% CI 0.87-1.60)
- IRR 1.18
- Findings in T2D unchanged after additional adjustment for retinopathy and nephropathy
Dementia and cerebrovascular disease, age-sex-height-adjusted VPT threshold for DPN
- Results were similar using the adjusted threshold
Original publication
Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease. Diabetes Obes Metab. Published 10 May 2026. doi:10.
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