Associations of time in tight range, time in range, and glycated hemoglobin with albuminuria in type 1 diabetes: A cross-sectional study
Authors' conclusion
TITR is independently associated with the risk of albuminuria in T1D, exhibiting a similar pattern to TIR but a different pattern from HbA1c. Very high TITR and TIR may provide information predicting albuminuria risk beyond HbA1c levels.
Study context
- Population
- Individuals with T1D with 14-day raw continuous glucose monitoring (CGM) data
- Participants
- 615 individuals
- Exposure
- Associations of time in tight range (TITR), time in range (TIR) and HbA1c with albuminuria
- Outcome
- Albuminuria (spot urine albumin-to-creatinine ratio ≥ 30 mg/g); OR per 10 % increase in TITR
Main finding
As reported in the abstract
Albuminuria per 10 % increase in TITR
Adjusted OR per 10 % increase in TITR
0.98
95 % CI 0.96–0.99p = 0.002
Observational data: associations, not effects.
Further findings
Albuminuria per 10 % increase in TIR
- Adjusted OR per 10 % increase in TIR
- 0.97 (95 % CI 0.96-0.99; p < 0.001)
Restricted cubic spline analysis
- Albuminuria risk decreased with increasing TITR and TIR, plateaued near HbA1c 7 %, but further decreased at very high TITR and TIR levels; HbA1c had a single threshold
Original publication
Associations of time in tight range, time in range, and glycated hemoglobin with albuminuria in type 1 diabetes: A cross-sectional study. Diabetes Res Clin Pract. Published 9 June 2025. doi:10.
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