Safety Event Outcomes and Glycemic Control with a Hybrid Closed-Loop System Used by Chinese Adolescents and Adults with Type 1 Diabetes Mellitus
Authors' conclusion
Chinese adolescents and adults, some of whom met target A1C at baseline, safely achieved significantly improved glycemia with 1 month of MiniMed 770G system use when compared to open-loop insulin delivery.
Study context
- Population
- Chinese adolescents (n = 12; mean ± SD 15.5 ± 1.1 years) and adults (n = 50; 37.6 ± 11.1 years) with T1D; baseline A1C 7.1% ± 1.0%12 adolescents · 50 adults
- Participants
- 62 participants
- Exposure
- Hybrid Closed-loop (HCL) Auto Mode vs open-loop Manual Mode run-in
- Outcome
- TIR (70-180 mg/dL)
Methodological detailsrun-in vs study period comparison
- Run-in vs study period comparison
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Time below range (TBR) (<70 mg/dL), subgroup with baseline A1C <7.0% (n = 29)
- TBR reduced from run-in to Auto Mode
- 5.6% to 2.0%
- Subgroup analysis
Time above range (TAR) (>180 mg/dL), subgroup with baseline A1C ≥7.5% (n = 21)
- TAR reduced from run-in to Auto Mode
- 31.6% to 20.8%
- Subgroup analysis
Achieving combined recommendations for time at sensor glucose ranges (time in range (TIR) >70%, TBR <4%, TAR <25%) · baseline to study end
- Percentage achieving combined targets increased with Auto Mode use
- 24.2% at baseline to 77.4% at study end
Total daily insulin dose
- Total daily insulin dose reduced
- 42.8 ± 19.8 to 40.7 ± 18.9 U (P = 0.013)
Safety
Severe hypoglycaemia, diabetic ketoacidosis (DKA) and serious adverse events
- There were no severe hypoglycaemic, DKA or serious adverse events
Original publication
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