The Advanced Hybrid Closed Loop Improves Glycemia Risk Index, Continuous Glucose Monitoring Index, and Time in Range in Children with Type 1 Diabetes: Real-World Data from a Single Center Study
Authors' conclusion
AHCL provides not only an improvement in TIR but also a significant improvement in both GRI and COGI at 6 months.
Study context
- Population
- Children with T1D who started advanced hybrid closed loop (AHCL), with baseline and 6-month continuous glucose monitoring (CGM) data; mean age 10.95 ± 3.41 years, diabetes duration 3.85 ± 2.67 years
- Participants
- 45 children
- Exposure
- AHCL at 6 months vs baseline
- Outcome
- Change in Glycemia Risk Index (GRI) score
- Follow-up
- 6 months
Methodological detailssingle-centre, real-world data, before-after comparison, Paired t-test used for analyses
- Single-centre
- Real-world data
- Before-after comparison
- Paired t-test used for analyses
Main finding
As reported in the abstract
GRI score
Baseline
35.66
mean · ± 17.46
6 months
22.83
mean · ± 9.08
P < 0.001
Observational data: associations, not effects.
Further findings
GRI zone A · 6 months
TIR · 6 months · increased significantly
P < 0.001
| Outcome | 6 months | Baseline | P value |
|---|---|---|---|
| COGI · 6 monthsImproved | 82.90 ± 7.72 | 72.59 ± 12.44 | P < 0.001 |
Original publication
The Advanced Hybrid Closed Loop Improves Glycemia Risk Index, Continuous Glucose Monitoring Index, and Time in Range in Children with Type 1 Diabetes: Real-World Data from a Single Center Study. Diabetes Technol Ther. Published 1 September 2023. doi:10.
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