Hypoglycemia and Hyperglycemia According to Type of Diabetes: Observations During Fully Closed-Loop Insulin Delivery in Adults With Type 1 and Type 2 Diabetes
Primary result · Time in hypoglycemia <70 mg/dLResult — go to the resultMean difference 0.46 percentage points 95% CI 0.23–0.70Authors' conclusion
Using the FCL system, hypoglycemia and marked hyperglycemia exposure were lower in type 2 diabetes than in type 1 diabetes.
Study context
- Population
- Adults with T1D or insulin-treated T2D using CamAPS HX fully closed-loop (FCL) insulin delivery, no user input at mealtimes
- Participants
- 52 adults
- Comparison
- T2D vs T1D during fully closed-loop insulin delivery
- Primary endpoint
- Time in hypoglycemia <70 mg/dL and marked hyperglycemia >300 mg/dL by type of diabetes
- Follow-up
- 8 weeks, 24-hour period
Methodological detailssingle-centre, unrestricted-living conditions
- Single-centre
- Unrestricted-living conditions
Primary result
Time in hypoglycemia <70 mg/dL · 24-hour period
Mean difference
0.46 percentage points
95% CI 0.23–0.70
P < 0.001
By group
T1Dvs T2D
mean difference 0.46 percentage points (95% CI 0.23–0.70); P < 0.001
As reported in the abstract
Further findings
Median
| Outcome | T1D | T2D | Mean difference (percentage points) (95% CI) | P value | |
|---|---|---|---|---|---|
| Time in marked hyperglycemia >300 mg/dL · 24-hour periodKey outcome | 9.3% (IQR 6.9–11.8) | 1.8% (IQR 0.6–3.5) | 7.8 (5.5–10.0) | P < 0.001 | |
| −5051015Difference, percentage points (linear scale) |
Original publication
Hypoglycemia and Hyperglycemia According to Type of Diabetes: Observations During Fully Closed-Loop Insulin Delivery in Adults With Type 1 and Type 2 Diabetes. J Diabetes Sci Technol. Published 13 April 2024. doi:10.
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