Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children
Main findingResult — go to the resultHazard ratio 1.71 95% CI 1.16–2.51Authors' conclusion
This study reveals an sICM profile that is dysregulated during the preclinical stage of type 1 diabetes, and identifies sPD-1 as a pathophysiologically-relevant molecule that is associated with disease progression, offering a potential target for early interventions in autoimmune diabetes.
Study context
- Population
- Children: islet autoantibody-positive, recent-onset T1D and healthy, from two cohorts; AAb+ children followed up for progression to T1D
- Exposure
- AAb+ children vs recent-onset T1D vs healthy children; progressors (AAbP) vs non-progressors (AAbNP)
- AAb+n = 57
- Recent-onset T1Dn = 79
- Healthyn = 44reference
- Outcome
- Serum levels of 14 soluble immune checkpoint molecules (sICM) related to T1D progression
Methodological detailstwo cohorts
- Two cohorts
Main finding
As reported in the abstract
Hazard ratio
1.71
95% CI 1.16–2.51
P = 0.007
High sPD-1
HR 1.71 (95% CI 1.16–2.51); P = 0.007
Observational data: associations, not effects.
Original publication
Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children. Diabetologia. Published 12 January 2024. doi:10.
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