The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes
Authors' conclusion
Our data indicate that during progression to stage 3 type 1 diabetes, rates of change in declining glucose and insulin sensitivity are not significantly different between progressors aged <14 years and progressors aged ≥14 years. These data suggest there is a predictable course of declining metabolic function during the progression to type 1 diabetes that is not influenced by age.
Study context
- Population
- Autoantibody-positive participants followed longitudinally in DPT-1 who progressed to stage 3 T1Dautoantibody-positive
- Participants
- 658 participants
- Comparison
- Progressors aged <14 years vs progressors aged ≥14 years
- Primary endpoint
- Yearly rate of decline in beta cell glucose sensitivity and insulin sensitivity (OGTT modelling)
- Follow-up
- Study entry to stage 3 T1D onset
Methodological detailslongitudinal
- Longitudinal
Primary result
As reported in the abstract
Yearly rate of decline in beta cell glucose sensitivity
<14 years
−13.7
median · IQR 21.2 · pmol min-1 m-2 [mmol/l]-1
≥14 years
−11.9
median · IQR 21.5 · pmol min-1 m-2 [mmol/l]-1
P = 0.52
Further findings
Median, ml min-1 m-2
| Outcome | <14 years | ≥14 years | P value |
|---|---|---|---|
| Yearly rate of decline in insulin sensitivity · study entry to stage 3 T1D onsetNo significant difference | −22 (IQR 37) | −14 (IQR 40) | P = 0.07 |
T1D risk by age (entire DPT-1 cohort)
- Highest discriminant age for T1D risk
- 14 years
- Participants aged <14 years twice as likely to progress to T1D as those aged ≥14 years
Beta cell glucose sensitivity at study entry
- Impaired to a similar extent in progressors aged <14 and ≥14 years
Original publication
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes. Diabetologia. Published 2 December 2022. doi:10.
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