Metabolic predictors of pain, fatigue, depression and quality of life in people with long‐term type 1 diabetes—the Dialong study
Authors' conclusion
Long-term chronic hyperglycaemia may have a negative influence on pain and fatigue in people with type 1 diabetes. These results may assist health care workers in emphasizing the importance of strict glycaemic control in people with diabetes and identifying and treating type 1 diabetes-related pain and fatigue.
Study context
- Population
- Persons with T1D of ≥45 years duration (Dialong study)
- Participants
- 104 persons
- Outcome
- Associations of metabolic parameters (mean 30 years' time-weighted HbA1c and LDL-C, current MetSO, AGEs, inflammatory markers, hypoglycaemia) with pain, fatigue, depression and quality of life (QoL)
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Associations of mean time-weighted HbA1c with questionnaire scores (standardized regression coefficients, beta)
Higher mean time-weighted HbA1c and bodily pain (RAND-36 bodily pain; lower scores = more pain), beta (p-value)
−0.3
<0.001
Higher mean time-weighted HbA1c and total fatigue, beta (p-value)
0.2
0.001
Observational data: associations, not effects.
Original publication
Metabolic predictors of pain, fatigue, depression and quality of life in people with long‐term type 1 diabetes—the Dialong study. Diabet Med. Published 29 November 2022. doi:10.
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