Causal associations between type 1 diabetes and COVID-19 infection and prognosis: a two-sample Mendelian randomization study
Authors' conclusion
Type 1 diabetes had a causal effect on severe COVID-19 and death after COVID-19 infection. Further mechanistic studies are needed to explore the relationship between type 1 diabetes and COVID-19 infection and prognosis.
Study context
- Population
- European population; T1D GWAS summary statistics (discovery: 15,573 cases, 158,408 controls; replication: 5913 cases, 8828 controls)
- Comparison
- Genetically predicted T1D vs no T1D
- Outcome
- COVID-19 infection and prognosis
Methodological detailsreverse Mendelian randomization (MR) analysis, discovery and replication samples
- Reverse MR analysis
- Discovery and replication samples
Main finding
As reported in the abstract
Severe COVID-19: OR (95% CI 1.034 to 1.114), pFDR=1.15×10-3
1.073
COVID-19 death: OR (95% CI 1.033 to 1.119), pFDR=1.15×10-3
1.075
Further findings
Severe COVID-19 and COVID-19 death (replication sample)
- Severe COVID-19: OR (95% CI 1.029 to 1.081), pFDR=1.59×10-4
- 1.055
- COVID-19 death: OR (95% CI 1.026 to 1.081), pFDR=3.50×10-4
- 1.053
COVID-19 positive, hospitalized COVID-19, time to end of symptoms (colchicine and placebo)
- No causal association with T1D
Reverse causality
- Reverse MR analysis showed no reverse causality
Original publication
Causal associations between type 1 diabetes and COVID-19 infection and prognosis: a two-sample Mendelian randomization study. BMJ Open Diabetes Res Care. Published 13 June 2023. doi:10.
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